Diphenidol poisoning suicide cases are becoming increasingly common in both clinical and forensic settings. This trend poses significant challenges for forensic practitioners, as identifying these cases can be quite difficult. One of the main obstacles in diagnosing diphenidol poisoning is the lack of distinct pathological changes in fatal cases. As a result, it is hard to determine the lethal concentration of diphenidol (DPN) in the blood, which is essential for confirming the cause of death. Furthermore, the presence of other toxins and drugs in these cases can complicate the identification process, making it even more challenging for forensic experts to pinpoint diphenidol as the primary cause of death. To address these challenges, a thorough review of existing information on diphenidol poisoning has been conducted to provide a comprehensive understanding of the subject from a forensic perspective. By summarizing the current knowledge on diphenidol, this review aims to serve as a reference for forensic practitioners dealing with such cases. Additionally, it seeks to shed light on the need for further research in the field of diphenidol poisoning. The goal is to improve the identification and diagnosis of diphenidol-related deaths, ultimately enhancing the accuracy and effectiveness of forensic investigations. By advancing the understanding of diphenidol poisoning, forensic experts can better equip themselves to tackle the complexities associated with these cases, leading to more accurate and informed conclusions in the future. This, in turn, can help to mitigate the increasing trend of diphenidol poisoning suicide cases and provide valuable insights for prevention and intervention strategies. Link: https://pubmed.ncbi.nlm.nih.gov/40393192/