Fish gallbladder poisoning is a serious and potentially life-threatening condition that occurs when an individual consumes the gallbladder of a fish. This can lead to damage to multiple organs, including the heart, liver, and kidneys, and can result in fatal outcomes in severe cases. A recent case highlights the dangers of this condition, involving a 56-year-old female farmer who consumed the gallbladder of a black carp in an attempt to treat her cough, based on a folk remedy. Unfortunately, this decision led to severe health consequences, including abdominal pain, diarrhea, and anuria, which is the inability to produce urine. The patient's condition quickly deteriorated, and she developed multiple organ dysfunction syndrome, which required immediate medical intervention. She underwent a range of treatments, including oxygen therapy, anti-infective treatment, hepatoprotective measures, acid suppression, and gastric protection, as well as management for heart failure and anemia. The patient also required maintenance hemodialysis, which is a treatment that filters waste products from the blood when the kidneys are no longer able to perform this function. Thankfully, after nearly two weeks of hospitalization and continued treatment, the patient's condition began to improve, and she was eventually discharged. However, she required ongoing maintenance hemodialysis for approximately three months to support her renal function until it was fully restored. This case highlights the importance of early recognition, prompt treatment, and public health education to prevent similar incidents of fish gallbladder poisoning, which is primarily caused by toxins such as histamine, hydrocyanic acid, and cyprinol sulfate. By maintaining clinical vigilance and raising awareness about the dangers of consuming fish gallbladders, healthcare professionals can help prevent severe multiorgan dysfunction and promote favorable outcomes for individuals who may be at risk of this condition. Link: https://pubmed.ncbi.nlm.nih.gov/40355232/